Meta-analysis of closed cannulated screw fixation versus open plate fixation for sanders ii, iii calcaneal fractures in fitness enthusiasts and athletes

Objective: To compare closed cannulated screw fixation and open plate fixation in the treatment of Sanders II, III calcaneal fractures. Methods: Randomized controlled studies searching from PubMed, Embase and Cochrane library from the establishment of the database to September 2022. The retrieved literature was screened according to inclusion and exclusion criteria. And RevMan 5.3 software was used for Meta analysis. Results: A total of 10 studies were included with 1014 feet of 1010 cases, including 508 feet of 506 cases in the closed group (experimental group) and 506 feet of 504 cases in the open group (control group). Meta analysis results: the time to operation of the closed group was shorter than that of the open group [ MD = -2.15, 95% CI ( -3.62, -0.68 ), P < 0.05 ]; operation time of the closed group was shorter than that of the open group [ MD = -14.95, 95% CI ( -26.01, -3.90 ), P < 0.05 ];bigger Gissane angle of the closed group [ MD = 0.98, 95% CI ( 0.28, 1.67 ), P < 0.05 ]; higher calcaneus of the closed group [ MD = 0.61, 95% CI ( 0.12, 1.11 ), P < 0.05 ]; less postoperative complications of the closed group [ OR = 0.29, 95% CI ( 0.17, 0.52 ), P < 0.05]; No statistically significant differences in postoperative Bohler Angle [ MD = 0.44, 95% CI (-0.50, 1.38), P > 0.05 ], calcaneus width [ MD = 0.78, 95% CI (-0.17, 1.72), P > 0.05 ], and AOFAS scores [ MD = 1.02, 95% CI (-3.46, 5.50), P > 0.05 ] were observed between the two groups. Conclusions: Closed cannulated screw fixation are superior to open plate fixation in the treatment of Sanders II, IIIcalcaneal fractures with shorter operation time, and less postoperative complications. There is no significant difference between the two surgical methods in restoring ankle function (AU)

Clinical Utility of Automated Structural Brain Volume Analysis in MRI for Evaluating Temporal Lobe Epilepsy in Fitness Athletes

Background: Investigating alterations in brain volumes among individuals with magnetic resonance-negative temporal lobe epilepsy (MRIn-MTLE) is of particular interest in the context of athletes and fitness enthusiasts. In this study, we aimed to examine these brain volume changes and their potential implications. Methods: We conducted a retrospective analysis of T1-weighted brain images from MRIn-MTLE patients and healthy controls (HC) who were actively engaged in athletics or fitness activities. Brain regions were segmented and quantified using FreeSurfer software, and we compared the volumes of ipsilateral brain regions between patients and controls. We employed Feature Explorer software, based on Pyradiomics, to construct a classification model using volume parameters and assessed its effectiveness in distinguishing between MRIn-MTLE patients and controls. Results: Significant differences in brain volumes were observed in various regions of the brain, both on the left and right sides, among both HC and MRIn-MTLE patients. Notably, these differences varied by gender. In males, the estimated total intracranial volume (eTIV) and the volumes of specific regions in the left hemisphere were larger in the HC group than in the MRIn-MTLE group. In females, certain brain regions in the right hemisphere were smaller in MRIn-MTLE patients compared to the HC group. The classification model achieved an area under the curve (AUC) of 0.780 and an accuracy of 0.721. Conclusions: Our study identified notable reductions in brain volumes among MRIn-MTLE patients who are athletes or fitness enthusiasts. Further investigations are needed to understand the underlying physiological and anatomical factors contributing to these differences. The findings suggest that brain volume measurements can serve as valuable features for constructing classification models to differentiate MRIn-MTLE patients from healthy individuals in the athletic and fitness community. (AU)

Percutaneous Kyphoplasty Enhanced with Calcium and Zoledronic Acid for Managing Thoracolumbar Compression Fractures in Athletes with Osteoporosis and Fitness Concerns

Background: Athletes and fitness enthusiasts often encounter thoracolumbar compression fractures due to rigorous physical activities. Combining calcium (Ca) and zoledronic acid (ZOL) with percutaneous kyphoplasty (PKP) has shown promising clinical efficacy in elderly patients with osteoporotic thoracolumbar compression fractures (OTCF). However, the potential benefits of this approach in athletes and fitness enthusiasts require further investigation. Methods: We conducted a retrospective analysis of 295 athletes and fitness enthusiasts (mean age 75.91±3.74 years) with OTCF who underwent PKP. Patients were divided into three groups: PKP+Ca (n=92), receiving 1500mg/d Ca carbonate post-surgery; PKP+ZOL (n=98), receiving 5mg ZOL intravenously post-surgery; and PKP+Ca+ZOL (n=105), administered with a combination of Ca and ZOL post-surgery. A two-year follow-up was conducted, and clinical and imaging data were recorded and analyzed before and after treatment. Results: There were no significant differences in general information, lumbar bone mineral density (BMD), visual analog scale (VAS), Oswestry dysfunction index (ODI), and bone marker levels among the three groups before treatment. In the 3rd, 6th, 12th, and 24th months post-treatment, the PKP+Ca+ZOL group exhibited higher vertebral heights compared to the PKP+Ca and PKP+ZOL groups. Additionally, in the 6th, 12th, and 24th months post-treatment, the PKP+Ca+ZOL group demonstrated lower kyphosis than the PKP+Ca and PKP+ZOL groups. Furthermore, in the 12th and 24th months post-treatment, the PKP+Ca+ZOL group had higher BMD values than the PKP+ZOL and PKP+Ca groups. VAS scores in the PKP+Ca+ZOL and PKP+ZOL groups were significantly lower than those in the PKP+Ca group. ODI scores and bone marker concentrations were also lower in the PKP+Ca+ZOL group compared to the other groups. (AU)

Exploring the feasibility and safety of ropinirole combined with nerve growth factor for enhancing neurological health in football players

Objective: This study aims to investigate the viability and safety of utilizing ropinirole in combination with nerve growth factor for the management of neurological health in football players.Methods: A total of 92 athletic inpatients diagnosed with Parkinson's disease were enrolled in this study from December 2018 to December 2020. They were randomly divided into two groups: the control group and the research group, each comprising 46 athletic patients. The control group received nerve growth factor treatment, while the research group received a combination of ropinirole and nerve growth factor. Various serum markers, brain nerve factors, quality of life indicators, therapeutic outcomes, and safety profiles were evaluated and compared between the two groups.Results: Following treatment, both groups exhibited a significant increase in superoxide dismutase (SOD) levels compared to baseline, accompanied by substantial reductions in the levels of interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), and nuclear factor-kappa B P65 (NF-κB P65). Moreover, the research group demonstrated significantly higher SOD levels and lower IL-1β, TNF-α, and NF-κB P65 levels compared to the control group (P<0.05). The levels of ciliary neurotrophic factor (CNTF), brain-derived neurotrophic factor (BDNF), dopamine (DA), and serotonin (5-HT) significantly increased in both groups post-treatment, with the research group exhibiting notably higher levels of these factors compared to the control group (P<0.05). Assessment of cognitive function (Montreal Cognitive Assessment - MoCA), balance (Berg Balance Scale - BBS), and activities of daily living (ADL) scores revealed significant improvements in both groups after treatment. However, the research group displayed higher MoCA and BBS scores and lower ADL scores than the control group (P<0.05). (AU)

Network pharmacology analysis of Yi-Shen-Gu-Ta i-Ke-Li for recurrent spontaneous abortion in female fitness and athletic populations

Background: Yi-Shen-Gu-Tai-Ke-Li (YSGTKL), a renowned traditional herbal formula, has demonstrated clinical efficacy in addressing recurrent spontaneous abortion (RSA). Despite its widespread utilization in China, the current body of evidence regarding the effectiveness of its herbal components remains insufficient, and the underlying mechanisms of action remain enigmatic. This study endeavors to unravel the mechanisms responsible for the therapeutic effectiveness of YSGTKL in treating RSA, particularly within the context of female fitness and athletic populations. Methods: YSGTKL comprises various herbal plants, selected based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Specific drug targets associated with RSA were meticulously identified and corroborated using multiple reputable sources, including DrugBank, GeneCards, and Online Mendelian Inheritance in Man. The GEO database was leveraged to pinpoint differentially expressed genes (DEGs) relevant to RSA within female fitness and athletic populations. Subsequently, a comprehensive drug-compound-gene-disease network was meticulously constructed and visualized using Cytoscape software. Functional insights were gleaned through Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Within this network, a subset of hub genes was discerned through a protein-protein interaction (PPI) network analysis, specifically tailored to female fitness and athletic populations. To validate key active ingredients and core targets, molecular docking analyses were meticulously performed, taking into account the unique physiological aspects of female athletes and fitness enthusiasts. (AU).

Combined effect of ultrasound and sodium bicarbonate marination on chicken breast tenderness and its molecular mechanism.

The objective of this study was to explore the combined effect of ultrasound (20 kHz ultrasound probe (12 mm diameter), an output power of 350 W for 5 min (on-time and off-time pulse durations of 2 s and 3 s, respectively)) with low concentration (0.2 M) sodium bicarbonate solution (USB) on chicken breast tenderness and its preliminary molecular mechanism. Therefore, myofibril fragmentation index (MFI), filtering residues, cooking loss, shear force, histology of meat as well as SDS-PAGE, circular dichroism (CD), synchronous fluorescence spectroscopy, differential scanning calorimetrv (DSC) of actomyosin were investigated and compared with untreated (Control), deionized water (DW), ultrasound in deionized water (UDW), 0.2 M sodium bicarbonate solution (SB), respectively. The results showed that USB can effectively increase MFI, and reduce filtering residues, cooking loss and shear force by compared with UDW or SB. Furthermore, myofibril was presented with the largest interfibrillary spaces and the highest degree of actomyosin dissociation in USB group. The increase in α-helix content and decrease in fluorescence intensity of tyrosine and tryptophan implied that USB caused the conformation change in actomyosin. Additionally, actomyosin in USB group became more sensitive to temperature. Therefore, the treatment of ultrasound combined with low concentration of sodium bicarbonate accelerated actomyosin degeneration was considered as a promising and efficient technique in meat processing, especially for the fitness enthusiasts.